SportsLine's model reveals its Week 5 Fantasy football projections, PPR rankings, start-sit advice for sites like CBS Sports, ESPN and Yahoo

NFL Week 5 is here, so let's look at the odds and make some picks and predictions for the next weekend of the 2025 regular season.

Week 5 of the 2025-26 NFL regular season officially gets underway on Thursday, October 2, with a Thursday Night Football primetime clash featuring the NFC West rival San Francisco 49ers and Los Angeles Rams at SoFi Stadium.

ESPN's Don Van Natta Jr. was the first to report on the development.

Here's the latest on what's happening around the league entering Week 5: The Ravens will go the rest of the 2025 season with defensive tackle Nnamdi Madubuike, as head coach John Harbaugh announced on Monday that a neck injury was ending his year.

One month of the 2025-26 NFL regular season is in the books, and now it's time to kick off October with Week 5 set to kick off on Thursday, October 2, with an NFC West showdown in primetime. The action gets underway in primetime on Prime Video when the Los Angeles Rams welcome the

Bleacher Report's experts waved goodbye to a mediocre September and welcomed a new month with high aspirations.

Mike Florio and Chris Simms preview a Week 5 Sunday Night Football showdown between the Patriots and Bills at Highmark Stadium, analyzing a shocking spread and sharing why Josh Allen's squad is on upset alert at home.

SportsLine AI evaluated the Week 5 NFL odds and revealed its NFL predictions, NFL score predictions and NFL betting picks for every game