The FDA approved oral remibrutinib (Rhapsido) as a second-line treatment for chronic spontaneous urticaria (CSU), or chronic ...

HIV’s Tat protein blocks autophagy in macrophages, letting Mtb thrive. This may explain why HIV patients face higher TB risk even on ART.

Close monitoring of HIV viral load is crucial to prevent LLV among HIV-positive patients on ART, particularly older adults with low CD4+ counts and a history of PI use.

Researchers at the University of Washington and Fred Hutch found that CARD8, an inflammasome sensor, detects HIV-1 in macrophages during cell-to-cell viral transmissions from infected T cells. HIV can ...

Although there is still no cure for human immunodeficiency virus (HIV), the early introduction of highly active antiretroviral therapy (HAART) has been instrumental in significantly reducing mortality ...

The development of new classes of antiretroviral drugs, such as integrase inhibitors and CCR5-antagonistic entry inhibitors, has opened the possibility of considering regimens without NRTIs (Table 1).

Abstract: Mutations in HIV-1 drug targets can cause reduced affinity to antiretroviral inhibitors, leading to the emergence of resistant variants resulting in failure of treatment in infected ...

Following up on their previous work, the authors investigated whether HIV-1 cell-to-cell transmission activates the CARD8 inflammasome in macrophages, a key question given that inflammasome activation ...

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...