Siglec-15 has traditionally been understood as an immune checkpoint molecule, primarily located on the cell membrane where it suppresses T-cell function. However, the new research revealed that in SHH ...

Living organisms share an ancestor called the last universal common ancestor, or LUCA. LUCA is estimated to have lived ...

Scientists call this speck LUCA — the Last Universal Common Ancestor. Since the concept of LUCA first emerged, it has ...

All life on Earth shares a common ancestor that lived roughly four billion years ago. This so-called "last universal common ...

Researchers describe a rare type of gene family, known as “universal paralogs”, that provides insight into evolutionary history predating the last universal common ancestor of all life. Detailed ...

Membrane proteins are vital for cellular signaling, transport, and communication, making them attractive drug targets despite their challenging properties. Advances in mass spectrometry have enabled ...

Known as viral eukaryogenesis, this idea was first proposed in 2001 by Masaharu Takemura, a molecular biologist at the Tokyo University of Science. He suggested the nucleus of eukaryotic cells arose ...

Study findings map out a new way in which antiviral signals engage with cellular metabolism to balance defense and repair.

When our body fights an infection, the immune system must quickly activate defenses and trigger a beneficial inflammatory response. But it is just as important to resolve that inflammation and return ...

Schematic of an active cell membrane. In a typical active biological process, active proteins (shown in a variety of colors) in a cell membrane (shown in blue) interact with various biological ...

The human brain is the seat of memory, identity and decision-making—yet few treat its health with the same seriousness as heart or lung function. For Harvard neuroscientist Dr. Rudy Tanzi, one of the ...