As the brain ages, many cell types succumb to senescence. How does this start? In the September 10 Nature Aging, scientists led by Wei Cai, Zhengqi Lu, and Quentin Liu at Sun Yat-Sen University, ...

Some evidence suggests that regular consumption of fish, nuts, fruits, veggies, and whole grains, aka the Mediterranean diet, reduces a person’s risk of dementia. APOE4, on the other hand, increases ...

Sponsor Chan Zuckerberg Biohub Network and the Chan Zuckerberg InitiativeDue Date November 13, 2025 ...

The network provides high-quality brain tissue to scientists and clinicians and supports major initiatives on research into neurological disorders, including the aims of the Ministerial Action Group ...

Summary The PS1 P264L knock-in mouse line was derived using a two-step mutagenesis strategy similar to that used to generate the TgAPPSwe-KI line (Reaume et al., 1996). An advantage to this model is ...

Friend or foe? The debate about disease-associated microglia persists eight years after their discovery. If only there was a way to interrogate DAMs in living people and see how they correlate with ...

Plasma p-tau217 has rapidly pushed to the forefront of Alzheimer’s biomarkers, proving as accurate at predicting plaques as amyloid PET. However, it is less clear how well this blood marker stacks up ...

This approach uses mesenchymal stem cells isolated from a patient’s own fat tissue to treat neurodegenerative diseases. The stem cells are supposed to assist in repair of damaged tissue and ...

With amyloid immunotherapy in clinical use, scientists need to find better ways to identify the patients most at risk of developing ARIA (see part 16 of this series). One of the biggest danger signs, ...

Finding genetic variants associated with Alzheimer’s disease has been easier than figuring out exactly how they heighten risk. In the September 3 Nature, scientists led by Jubao Duan at the University ...

While amyloid immunotherapy is slowly becoming more accepted in clinical use, its biggest drawback remains the risk of ARIA. Scientists continue to study which patients are most at risk, how to ...

This interactive resource organizes decades of data on biomarkers for Alzheimer's disease. Biomarker measurements from the cerebrospinal fluid and blood are curated from the primary literature and ...