Mac Jones is playing quarterback for the San Francisco 49ers on Thursday Night Football against the Los Angeles Rams. That means Brock Purdy isn't out there, a bummer for the 'Niners. It initially was ...

The Rams and 49ers are facing off in a battle for first place in the NFC West. Follow along for all the latest updates from the clash at SoFi Stadium.

Check out our +910 same-game parlay for TNF, which keys on Davante Adams leading the way on offense for the Rams vs. the 49ers on October 2, 2025.

The San Francisco 49ers travel to take on the Los Angeles Rams at SoFi Stadium as big Thursday Night Football underdogs.

At the moment, the 49ers and Rams are in a five-way tie for second place in the NFC, only behind the undefeated Philadelphia Eagles. The other 3-1 teams in the NFC are the Detroit Lions, Tampa Bay ...

Get the best bets, predictions, props & odds for Week 5's Thursday Night Football matchup between the 49ers and Rams on Thursday, October 2.

New Fanatics users can get up to $150 in bonus bets with the latest Fanatics Sportsbook promo code when wagering on Rams vs. 49ers on Thursday Night Football ...

An Eagles fan's rooting guide for Week 5 NFL action around the league, as the Birds can put more distance between themselves and NFC East foes.

The NFC West rivals will square off with the chance to take over first place in the division. The Los Angeles Rams and San Francisco 49ers sit atop the NFC West standings along with the Seattle ...

The San Francisco 49ers will duke it out with the Los Angeles Rams to begin Week 5. Follow along for live score updates and highlights from "Thursday Night Football." ...

The 49ers face the Los Angeles Rams tonight and - just hours before kick-off - reports confirmed they had signed a brand new quarterback to their roster.