HIV mystery uncovered: How the virus reprograms host cells to create perfect hiding places

For over three decades, HIV has played an elaborate game of hide-and-seek with researchers, making treating—and possibly even ...
Medscape

Update on the Development of HIV Entry Inhibitors

Previous experience with antiretroviral compounds has indicated that viral replication can be affected through the use of agents that target multiple steps in the HIV lifecycle. Even within the ...
The Scientist

A new path for HIV entry

A new study overthrows a long-held theory on how HIV finds its way into host cells. Rather than fusing directly with the host cell membrane, the virus is first engulfed by it to form a vesicle that ...
Fred Hutch

HIV’s secret sweet tooth: T cell glycosylation determines variant entry

At the cellular level, HIV-1 transmission involves a highly coordinated process whereby the virus binds to CD4 receptors and one of two coreceptors—CCR5 (R5) or CXCR4 (X4)—on host immune cells, ...
The Scientist

HIV entry and membrane lipid rafts

That assembly and release of HIV-1 particles takes place at the plasma membrane has been established for some time. It has also been suspected that the process additionally requires lipid rafts — ...
Nature

A new entry route for HIV

Over the last few years, a consensus has emerged as to the identity of the cell surface molecules required for infection by HIV-1 (ref. 1). The viral envelope protein first binds to CD4, a protein ...
Medscape

Update on the Development of HIV Entry Inhibitors

Interestingly, the anti-HIV-1 targets of triterpene analogs can vary depending on the side chain modification position. C-28 modified betulinic acid analogs are potent HIV entry inhibitors, while C-3 ...