C&EN

Design, Synthesis, and Proof of Concept of Balanced Dual Inhibitors of Butyrylcholinesterase (BChE) and Histone Deacetylase 6 (HDAC6) for the Treatment of Alzheimer’s Disease

School of Pharmacy, China Pharmaceutical University, Nanjing 211198, People’s Republic of China ...

ORYZON to Participate in Upcoming Events in September and October

Oryzon Genomics, S.A. (ISIN Code: ES0167733015, ORY), a clinical-stage biopharmaceutical company and a European leader in epigenetics, announced today that its management will participate at the ...
Gut

Epigenetic therapies in hepatocellular carcinoma: emerging clinical tools and applications

Hepatocellular carcinoma (HCC) is the second leading cause of cancer death worldwide, largely due to the limited efficacy of ...
The EMBO Journal

Regulating histone acetyltransferases and deacetylases

Histone acetyltransferases and histone deacetylases regulate the acetylation of histones and transcription factors, and in doing so have major roles in the control of cell fate. Many recent results ...

Investigational Drug Tinostamustine to be Included in GBM AGILE Clinical Trial for Glioblastoma

Purdue Pharma L.P. ("Purdue") has entered into an agreement to have its pipeline medication tinostamustine included in the Phase 2/3 GBM AGILE (Glioblastoma Adaptive Global Innovative Learning ...

Italfarmaco Announces Exclusive Distribution Agreement with Multicare Pharma for DMD Treatment Givinostat in Brazil

Italfarmaco has entered into an agreement with Multicare for the regulatory approval and distribution of givinostat as a treatment for Duchenne ...
C&EN

A First-in-Class Chemical-Induced Proximity System Achieves Dose-Dependent Control of Tumor Protein P53 Gene Activation in Preclinical Models of Gastric Cancer

Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, United States Center for Integrated Chemical ...
IEEE

DeepHDAC3i: Leveraging an Interpretable Deep Learning-based Framework for the Accelerated Discovery of HDAC3 Inhibitors

Abstract: Epigenetics encompasses dynamic and reversible modifications that regulate gene activity without altering the underlying DNA sequence. Epigenetic processes, including non-coding RNA ...