Background: m.14487T>C, a missense mutation (p.M63V) affecting the ND6 subunit of complex I of the mitochondrial respiratory chain, has been reported in isolated childhood cases with Leigh syndrome ...
Inclusions of pathogenic deposits containing TAR DNA-binding protein 43 (TDP-43) are evident in the brain and spinal cord of patients that present across a spectrum of neurodegenerative diseases. For ...
In the management of neurological diseases, the identification and quantification of axonal damage could allow for the improvement of diagnostic accuracy and prognostic assessment. Neurofilament light ...
Occurrence and risk factors for apathy in Parkinson disease: a 4-year prospective longitudinal study
Correspondence to Dr K F Pedersen, The Norwegian Centre for Movement Disorders, Stavanger University Hospital, PO Box 8100, N-4068 Stavanger, Norway; kenfrp{at}online.no Background: Apathy is a common ...
Background Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis rarely causes visible lesions in conventional MRI, yet advanced imaging detects extensive white ...
a Department of Neurology, b Department of Clinical Epidemiology, Utrecht University Hospital, Utrecht, The Netherlands Professor J van Gijn, University Department of Neurology, Academic Hospital, ...
Background Development of autonomic failure is associated with more rapid disease course and shorter survival in patients with Parkinson’s disease and multiple system atrophy. However, autonomic ...
Objectives In utero exposure to antiepileptic drugs has previously been associated with adverse outcome among offspring, but evidence on longer term milestone development remains limited. We ...
Background/objective: Little is known about the long-term clinical course and management of patients with normal pressure hydrocephalus (NPH) treated by cerebrospinal fluid (CSF) shunting. Methods: We ...
Correspondence to Dr Benjamin Meir Jacobs, Centre for Neuroscience and Trauma, Blizard Institute, Barts and The London School of Medicine and Dentistry, London E1 2AT, UK; ben.meir.jacobs{at}gmail.com ...
Objective To explore if changes over time of plasma phosphorylated tau (p-tau)181 and neurofilament light chain (NfL) predict future tau and amyloid β (Aβ) PET load and cognitive performance, we ...
Background: Although neuropsychiatric complications are well recognised, the presentation of multiple sclerosis with cognitive or neuropsychiatric symptoms has generally been considered a rare ...
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