In a letter sent to Harvard President Alan M. Garber on Friday, Commerce Secretary Howard Lutnick alleges the university failed to follow several regulations outlined in federal law.

The Trump administration is warning Harvard University that it could take over its patents, worth hundreds of millions of dollars, if a review finds the university hasn’t complied with federal law, an escalation of the continuing negotiations between the White House and America’s oldest university.

After losing nearly $3 billion in research funding, Harvard University now risks losing control of its intellectual property in a latest Trump administration action.