Our genomic DNA is continuously damaged by endogenous factors such as reactive oxygen species, and also by environmental factors such as ultraviolet light, radiation, and chemicals. Failure to repair ...

This is a preview. Log in through your library . Abstract The regulation of DNA repair during serum stimulation of quiescent cells was examined in normal human cells, in fibroblasts from three ...

This is a preview. Log in through your library . Abstract The proximity of repair patches to persistent pyrimidine dimers in normal human cells and xeroderma pigmentosum group C and D cells was ...

Xeroderma pigmentosum, or XP, is a rare genetic disorder that prevents the skin from repairing sun damage. There are about 300 Americans currently living with XP, and the chances of being born in this ...

A rare inherited disorder, Xeroderma Pigmentosum (XP) is a photosensitive condition characterized by high susceptibility to skin cancers. XP follows the autosomal recessive pattern of inheritance.

Xeroderma pigmentosum (XP) is a rare autosomal recessive disease characterized by defective repair of ultraviolet (UV) irradiation-induced DNA damage and high risk of skin cancer. Thus, these patients ...

Nucleotide excision repair (NER) is a major conserved DNA repair pathway, which repairs various types of damage in the genome, such as those induced by ultraviolet light and environmental agents.

The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family ...

XPC protein acts as a sensor to detect various abnormalities in the DNA structure. The faithful repair of DNA is ensured by using the basal transcription factor TFIIH and XPA protein to verify the ...