Nature

Inhibition of Proteolytic Enzymes by Decarboxylated Amino-Acid Derivatives. Effect of Toluenesulphonyl(Tosyl)agmatine (4-Toluenesulphonamidobutylguanidine) on Thrombin and Trypsin

PROTEOLYTIC enzymes are known to catalyse the hydrolysis of specific amino-acid esters and amides 1. Specificity is usually determined by the side-chain of the amino-acid contributing the carbonyl ...
ascopubs.org

Pancreatic Proteolytic Enzyme Therapy Compared With Gemcitabine-Based Chemotherapy for the Treatment of Pancreatic Cancer

Phase II Trial of Continuous Dose-Intense Temozolomide in Recurrent Malignant Glioma: RESCUE Study All patients were seen by one of the investigators at Columbia University, and patients who received ...
WebMD

What Are Protease Inhibitors?

The term “protease inhibitor” refers to a class of medications rather than to a single medication. Specifically, they are antiviral drugs. But unlike the many, more common antiviral drugs that can be ...
Nature

A New Look at the Pathogenesis of the Meconium Aspiration Syndrome: A Role for Fetal Pancreatic Proteolytic Enzymes in Epithelial Cell Detachment

We hypothesized that fetal pancreatic digestive enzymes play a role in the lung damage after meconium aspiration. We studied the effect of meconium on the A549 alveolar epithelial cell line. The ...