Voltage-gated sodium channels are transmembrane proteins that underlie the rapid depolarisation phase of neuronal action potentials. Aberrant function or expression of specific channel ...

The transport of ions to and from a cell is controlled by pore-forming proteins embedded in the cell membrane. In particular, voltage-gated sodium channels (VGSCs) govern the transfer of sodium (Na +) ...

The addictive properties of opioids and the lives shattered by their misuse and overprescription are heavily chronicled chapters of the early 21st century. For over 2 decades, scientists in academia ...

Nat Clin Pract Neurol. 2008;4(3):159-169. Drug Primary clinical use Protective effect during administration in animal models? Effects of withdrawal in EAE Clinical study Phenytoin Treatment of ...

Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University report in Nature Communications a high-speed atomic force microscopy study of the structural dynamics of sodium ion ...

Imagine not feeling any pain when you stub your toe—or, conversely, experiencing constant burning pain or itching without an obvious cause. For some people, this is reality, caused by mutations in a ...