ascopubs.org

Use of Molecular Tumor Characteristics to Prioritize Mismatch Repair Gene Testing in Early-Onset Colorectal Cancer

Lymphovascular Invasion Is Independently Associated With Overall Survival, Cause-Specific Survival, and Local and Distant Recurrence in Patients With Negative Lymph Nodes at Radical Cystectomy The ...
Nature

Population frequency of Predicted pathogenic MisMatch Repair (MMR) gene variants in Lynch syndrome from bioinformatic analyses of the general population

Lynch syndrome is characterised by heterozygous germline mutations in the MisMatch Repair (MMR) genes and an increased risk of cancer. Previous population estimates based on cohorts with colorectal ...
Medical Xpress

Mismatch repair germline pathogenic variants could predispose to uveal melanoma

Mismatch repair (MMR) germline alterations are enriched among patients with uveal melanoma (UM), according to a study published online June 18 in JAMA Ophthalmology. Anaïs Le Ven, from Inserm U1339 in ...
Nature

Patterns of hypermutation shape tumorigenesis and immunotherapy response in mismatch-repair-deficient glioma

Cancer development is a cellular process rooted in genomic instability, fundamentally driven by acquired genetic alterations in either sequence or copy number. In human cancers, both of these ...
ascopubs.org

Microsatellite Peak Shifts in Polymerase Chain Reaction-Based Fragment Length Data Correlate With Microsatellite Instability Degree and Vary With Mismatch Repair Gene Defects ...

Microsatellite instability (MSI) arises from mismatch repair-deficiency (MMR-d) and is a predictor of immune checkpoint blockade (ICB) therapy response. Although MSI diagnostics typically yield a ...
Medscape

Mismatch Repair Status Linked to Endometrial Cancer Outcomes, Real-World Study Reveals

A retrospective study found that patients with mismatch repair (MMR)-deficient advanced or recurrent endometrial cancer had numerically longer overall survival (OS) than those with MMR-proficient ...
Los Angeles Times

Health Mystery Solved: New Study Reveals the Role DNA Plays in Huntington’s Disease

A new UCLA Health study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons that are most vulnerable in Huntington’s disease ...