A large systematic review on pregnant women living with HIV found that protease inhibitor–based antiretroviral therapy (ART) use was associated with increased risk of babies being born small or very ...
HIV-1 protease inhibitors (PIs) have long been central to antiretroviral therapy, directly targeting the enzyme responsible for processing viral polyproteins into functional units. Their efficacy, ...
A preliminary study to be presented at this year's European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) in Lisbon, Portugal (23-26 April), suggests that people living with HIV who ...
Haubrich RH, Riddler SA, Ribaudo H, et al. Initial viral decay to assess the relative antiretroviral potency of protease inhibitor-sparing, nonnucleoside reverse transcriptase inhibitor-sparing, and ...
Switching patients with HIV from a protease inhibitor–based antiretroviral therapy regimen to an integrase inhibitor–based regimen can be performed safely, with maintenance of high levels of virologic ...
HIV-1 protease inhibitors mimic the protease cleavage site with very tight binding to the protease to block its activity. The current most potent protease inhibitor is darunavir, which reaches levels ...
**Note: the release below is a special early release from the European Congress of Clinical Microbiology & Infectious Diseases (ECCMID 2022, Lisbon, 23-26 April). Please credit the conference if you ...
Association between FDG-PET and tumor vitality: Understanding the prognostic value of FDG uptake in early stage non-small cell lung cancer No significant financial relationships to disclose. This is ...
Ixabepilone and lapatinib for HER2-positive advanced breast cancer: Preclinical rationale and phase I trial Background: Preclinical studies show that HIV protease inhibitors such as nelfinavir (N) ...
Forbes contributors publish independent expert analyses and insights. William A. Haseltine, Ph.D., covers genomics and regenerative medicine This article is more than 4 years old. SARS Inhibited (2006 ...
A team of San Diego Supercomputer Center (SDSC) researchers recently created a pharmacophore model and conducted data mining of the database of drugs approved by the U.S. Federal Drug Administration ...
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