Checkpoint inhibitors play a critical role in immunotherapy. Unfortunately, they don’t work all the time. For reasons that have been largely unknown, some patients respond to checkpoint inhibitor ...

As gene regulation changes in Alzheimer’s disease, scientists believe that histone deacetylases (HDACs) go into overdrive, shutting down transcription of certain genes. Consequently, several research ...

Epigenetic mechanisms have a key role in the control of biological processes, and chromatin alterations may lead to the onset and progression of many diseases, first of all cancer. Unlike genetic ...

Immunotherapies have revolutionized the care of many cancers, teaching the body's own immune cells to recognize and attack tumor cells. Leading the way are drugs known as checkpoint inhibitors, which ...

The HDAC inhibitor pipeline remains active, with several next-generation agents advancing in clinical trials. Abexinostat (Xynomic Pharmaceuticals) is in Phase III development for renal cell carcinoma ...

With an aim to grab band-width in the shared PD-1 space, Merck has partnered with Syntax to conduct combination studies of Keytruda with Entinostat in melanoma and lung cancer patients. Merck has ...

Abcam provides a full array of HDAC antibodies from all the four classes of deacetylase. Many vital cell programs such as regulation of transcription, progression of the cell cycle and other ...

Most pancreatic tumors are surrounded by a thick, nearly impenetrable wall of fibrosis— scar tissue—that makes it hard for drugs to access and destroy the cancer cells. Researchers at the Salk ...

Induction of histone acetylation in the nucleus accumbens (NAc), a key brain reward region, promotes cocaine-induced alterations in gene expression. Histone deacetylases (HDACs) tightly regulate the ...

Histone deacetylases (HDACs), closely associated with gene silencing, may have a broader role in the cell than previously thought. Research suggests that HDACs have been misclassified simply because ...

A drug with a past life as a potential anti-cancer agent might someday have a new job as "the pill" for men, new data in mice suggest. In a journal article published Feb. 20 in Proceedings of the ...