Scientists discovered why some neurons resist tau toxicity, identifying CRL5SOCS4 as a crucial defense and linking ...

Endosomal trafficking and protein sorting constitute fundamental processes that govern the intracellular localisation and recycling of membrane proteins in eukaryotic cells. Endosomes act as central ...

Researchers have uncovered a shared brain cell breakdown mechanism behind Alzheimer’s and Parkinson’s diseases, revealing how two different proteins can disrupt neurons in the same devastating way.

By Vijay Kumar Malesu New mouse data reveal that ageing neurons struggle to clear synaptic proteins, shifting the burden to microglia and exposing a critical vulnerability in brain protein maintenance ...

Much like humans generate mountains of garbage, our cells are constantly discarding proteins that are damaged or no longer needed. The cellular waste disposal system called the proteasome is best ...

Knowing which lysosomal proteins are enriched in which brain cell types will help better understand contribution to neurological disorders.

Activated T cells that carry a certain marker protein on their surface are controlled by natural killer (NK) cells, another cell type of the immune system. In this way, the body presumably curbs ...

When killer T cells of our immune system divide, they normally undergo asymmetric cell division (ACD): Each daughter cell inherits different cellular components, which drive the cells toward divergent ...

A collaboration unveils a novel strategy for identifying key proteins in organelle communication. This approach advances our ability to pinpoint proteins essential for organelle interactions within ...