A research team has uncovered a new mechanism involving astrocytes for treating Alzheimer's disease (AD) and proposed a novel therapeutic target. AD, a representative form of senile dementia, occurs ...
The Intracellular Quality Control Project at the Tokyo Metropolitan Institute of Medical Science has identified a molecular ...
The proprietary program targets a lactate–autophagy pathway to reactivate quiescent hair follicle stem cells. In a mouse model, a candidate achieved a hair-growth score comparable to that of 5% ...
Oxidative stress induced by 6-OHDA stimulates autophagy flux, which enhances STX17-mediated autolysosome formation, leading to the degradation of autophagosomal contents. However, in response to ...
Gliomas are a major cause of cancer-related deaths in younger adults. About 7,000 patients harbor a common genetic mutation that affects the enzyme isocitrate dehydrogenase 1. This mutated enzyme, ...
Concurrent Inhibition of The RAS Pathway and Autophagy As a Treatment Approach for Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is characterized clinically by poor survival and mechanistically by KRAS- and autophagy-dependent growth. We and others previously demonstrated that inhibition ...
Autophagy, which declines with age, may hold more mysteries than researchers previously suspected. In the January 4th issue of Nature Aging, it was noted that scientists from the Buck Institute, ...
Autophagy and lysosomal pathways orchestrate unconventional secretion of Parkinson's disease protein
Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells. Conventionally, proteins that are ...
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