The blood–brain barrier (BBB) is meant to protect the brain from noxious agents; however, it also significantly hinders the delivery of therapeutics to the brain. Several strategies have been employed ...

Getting drugs to the brain is difficult. The very thing designed to protect the brain's environment — the blood-brain barrier (BBB), tightly packed cells that prevent most substances from passing ...

Daiza Gordon watched her two younger brothers die when they were adolescents. They had Hunter syndrome, a rare, incurable disease — predominantly affecting boys — in which a gene for an important ...

Voyager Therapeutics, Inc.'s TRACER platform shows strong preclinical results for BBB-crossing gene therapies, securing multi-billion dollar deals with Novartis and Neurocrine, but lacks clinical ...

While this protects the brain from external threats, it also presents a major challenge for treating neurological diseases, as many potentially therapeutic compounds are unable to cross. One potential ...

New data show additional improvement and stabilization in clinical outcomes in MPS II with 104 weeks of tividenofusp alfa (DNL310) treatment in the open-label, single-arm Phase 1/2 study; sustained ...

The blood-brain barrier is a crucial protective membrane that evolved to shield the brain from pathogens and toxic substances that may be present in the blood. It also excludes the vast majority of ...