Multiple preseason injuries created serious questions about San Francisco’s offensive line stability and backfield depth heading into Week 1.

Given the injury problems the 49ers currently face with their two starting receivers, Jauan Jennings and Brendon Aiyuk, Purdy may have to rely on Kittle as a primary target this season. With Ricky Pearsall entering his sophomore season, lingering uncertainty about his inexperience could increase the team’s reliance on Kittle.